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中华关节外科杂志(电子版) ›› 2025, Vol. 19 ›› Issue (02) : 131 -142. doi: 10.3877/ cma.j.issn.1674-134X.2025.02.001

专家共识

髋膝关节置换手术止血中国专家共识
中华医学会骨科学分会关节外科学组   
  • 收稿日期:2025-04-22 出版日期:2025-04-01
  • 基金资助:
    国家自然科学基金面上项目(82272503)

Chinese expert consensus on hemostasis in hip and knee arthroplasty surgery

Surgery Group of the Orthopaedic Society of the Chinese Medical Association Joint   

  • Received:2025-04-22 Published:2025-04-01
引用本文:

中华医学会骨科学分会关节外科学组. 髋膝关节置换手术止血中国专家共识[J/OL]. 中华关节外科杂志(电子版), 2025, 19(02): 131-142.

Surgery Group of the Orthopaedic Society of the Chinese Medical Association Joint. Chinese expert consensus on hemostasis in hip and knee arthroplasty surgery[J/OL]. Chinese Journal of Joint Surgery(Electronic Edition), 2025, 19(02): 131-142.

随着全球人口老龄化加剧,骨关节炎等关节疾病患病率显著攀升,髋膝关节置换手术需求也随之增加。然而,手术效果受患者基础疾病(如高血压、糖尿病)、手术技术及假体选择等多因素影响,尤其是老年患者合并症复杂,进一步增加了手术风险与难度。术中及术后出血是髋膝关节置换术的重要挑战。老年及合并症患者常面临隐性失血与输血需求增加,易引发感染、输血反应等并发症。尽管现有指南关注围手术期血液管理,但术中止血的具体策略仍缺乏系统指导。因此,迫切需要深入研究与发展术中规范的止血操作,以减少出血量,降低输血相关风险,优化血液资源利用,促进患者术后康复,并缓解医疗系统压力。为此,共识专家组基于证据分级与专家讨论形成推荐意见,为手术止血提供标准化参考框架。共识强调临床实施需结合个体化评估,根据临床实际灵活应用。

With the accelerating global population aging, the prevalence of joint diseases such as osteoarthritis has risen markedly, driving an increasing demand for hip and knee arthroplasty. However, surgical outcomes are influenced by multiple factors, including underlying comorbidities of patients (e.g., hypertension and diabetes), surgical techniques, and prosthesis selection. The complexity of comorbidities in elderly patients further amplifies surgical risks and technical challenges. Intraoperative and postoperative hemorrhage remains a pivotal challenge in hip and knee arthroplasty. Elderly patients and those with comorbidities often experience hidden blood loss and elevated transfusion requirements, predisposing them to complications such as infections and transfusion-related adverse events. Although existing guidelines emphasize perioperative blood management, systematic guidance on intraoperative hemostatic strategies remains insufficient. Therefore, there is an urgent need to advance research and standardize intraoperative hemostatic protocols to reduce blood loss,minimize transfusion-associated risks, optimize blood resource utilization, enhance postoperative recovery, and alleviate healthcare system burdens. To address these issues, the consensus expert panel formulated evidencebased recommendations through evidence grading and multidisciplinary discussions, establishing a standardized reference framework for surgical hemostasis. This consensus underscores the necessity of individualized clinical implementation, advocating flexible adaptation based on real-world practice.

表1 GRADE证据和推荐强度
表2 可吸收止血材料
表3 可吸收止血材料的特点、功效、临床价值和应用方法
形态 特点 功效 临床价值 应用方法
· 有效覆盖大面积出血创面,即使不按压的情况下,也能快速形成稳定的血凝块 · 避免装置头端与创面直接接触
止血颗粒 由多个再生氧化纤维素细纤维缠绕形成的微小颗粒(100~500μm) 快速穿透血液,直达出血创面 · 凝血反应完成后,可以冲洗去除多余的未反应颗粒,减少残留 · 均匀喷洒,确保充分覆盖出血创面
· 再生氧化纤维素材质具有抗菌作用,减少感染风险 · 待棕黑色血凝块形成后冲洗去除多余颗粒
· 可以有效处理传统固体材料难以触及的出血点,或无明确出血点的出血,与创面充分接触 · 在组织缺损部位(空腔、浅凹或坑形缺损),先在病变部位的最深处涂抹流体明胶,然后一边回撤注射器(或导管)一边继续涂抹
流体明胶 质地均匀,细密黏稠的流体性状明胶基质 深入狭小腔隙,紧密附着创面 · 可以放置于活动性出血表面,形成稳定血凝块,不被血液冲走 · 对出血缝隙打入适量明胶基质
· 可术中使用清晰术野,多余基质易冲洗不残留,不影响后续操作 · 在流体明胶上方覆盖一张用无菌生理盐水润湿的纱布,确保止血剂与出血组织保持接触。可通过充分按压确保基质与创面充分接触
· 快速止血,清晰术中视野,缩短手术时间; · 根据创面形状分层塑形并贴附创面
纤丝 由短小细纤维压制而成,成棉絮状。 分层塑形,贴合于复杂创面 · 再生氧化纤维素材质具有抑菌作用,减少术后感染风险; · 充分按压后,止血成功将未形成棕褐色血凝块的部分去除
· 减少术后引流,助力高效医疗加速康复;
· 优良的生物可降解性 · 喷洒于创面
止血粉 表面不光滑的实心微球,(球径15~50 μm) 亲水性强,可浓缩血液,提高血细胞血小板浓度。 · 生物相容性好 · 喷洒粉末后,立即对喷洒部位加以适当的压力
· 应用于轻微渗血创面
化学胶 具有粘合性能的胶体 封闭粘合创面,处理高压力渗血 · 瞬间接着,快速完成汹涌活动性出血创面 · 在需要用胶的创面滴胶并涂抹均匀
· 胶体强度高可用于效粘合大血管吻合口等部位。
海绵 白色或微黄色、质轻软而多孔的海绵状物 吸附液体膨胀后压迫创面止血 · 帮助清晰术野,持续压迫出血创面 · 放置于渗血表面并持续性按压
· 可吸收,生物相容性好 · 止血完成后将吸血膨胀的明胶海绵去除避免占位效应
纱布 经纬编织结构,呈网格状,抗张力度强 轻薄,网状结构更牢固,牵拉撕扯不破碎 · 处理平整创面轻微渗血 · 贴附于轻微渗血表面
· 牢固不易破损,适合包裹或缠绕脏器 · 持续按压,待止血完成后去除未与血液反应的部分
非织布 非编织结构,由短纤维相互交织、紧密缠绕而成,毛毡状 厚韧紧实,具有形态记忆力 · 纤维更密集,止血速度更快 · 贴附于轻微渗血表面
· 结构牢固,腔镜下不掉飞絮,易于展开放置 · 持续按压,待止血完成后去除未与血液反应的部分
表面光滑致密,轻薄 贴附于浅表创面,形成凝胶屏障,隔离创面 · 生物相容性好,可吸收,无毒 · 吸除创面积血
· 无免疫原性反应 · 迅速将止血膜覆盖于出血创面并进行压迫
· 移除多余止血膜
蜂蜡与凡士林的混合物,具有软化性能 搓揉后变软可塑形,物理封堵骨性渗血 · 更柔软,无需加温软化,直接使用。 · 冲洗出血创面,保持创面清洁
· 更易成形,更易贴附骨面,只需更少量即可达到良好的止血效果。 · 软化骨蜡,涂于骨上渗血处
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